刘正言,男,江苏省徐州人。主任医师,副教授,复旦大学医学博士,美国加州大学(UCSF)博士后,多次国内外进修和培训。国内外学术交流:SocietyforNeuroscience.2003.NewOrleans,USA.;SocietyforNeuroscience.2004.SanDiego,USA.;AANS.2004.SanFrancisco,USA.;InternationalSocietyforCerebralBloodFlowandMetabolism.2005.Amstadam,Netherlands.InternationalNeurosurgeryEducationandResearch,2009.Florida,USA多次参加国外培训、进修、国内举办的学术活动和学术交流。专著:参编和翻译专著10余部,如:《现代神经外科学》、《实用外科学》、《实用神经病学》、《现代肿瘤学》、《中枢神经系统肿瘤》等。承担科研项目:2007-2011:国家十一五科技支撑计划重大项目---脑卒中外科综合治疗技术体系研究。1998.9-2001.12承担上海市医学发展重点课题:“去骨瓣减压术对局灶性脑缺血的保护机制及其前瞻性临床研究”。完成并通过鉴定。2003.3-2005.7在美国加州大学旧金山分校进修时主要从事脑缺血后内源性神经再生与功能重建的研究,如:炎症反应与神经再生;优越环境(EE)对脑缺血和放射治疗后神经再生的影响;EMX1基因对神经再生的影响;低血糖对神经再生的影响等多项课题。均已完成并发表多篇SCI文章。2006.1-2008.1承担华山医院科研课题“抗凋亡治疗对延长缺血诱导的内源性神经干细胞生存的研究”。目前已完成。2006.1起作为主要负责人之一承担“蒂清治疗脑胶质瘤与转移瘤前瞻、开放、对照临床研究”。目前正在研究中。发表论文及会议论文摘要:ChengyuXia,ZhengyanLiu?,RongZhang,YingMao,YinWan.Primaryintrinsicopticchiasmgerminoma.JournalofClinicalNeuroscience18(2011)860–862.(通讯作者)刘正言,潘力。颅咽管瘤的治疗。国外医学神经病学神经外科分册,1998,25(3):132~135刘正言,潘力,王滨江,王恩敏,张南,杨立群。伽玛刀和立体定向32P囊内放疗联合治疗颅咽管瘤。中国临床神经科学,1998,6(2):86~89刘正言,周良辅。去骨瓣减压术治疗大面积脑梗死的现状和进展。中国神经精神疾病杂志,2000,26(3):190~191刘正言,周良辅,黄峰平,毛颖。去骨瓣减压术治疗大面积脑梗死前瞻性临床研究方案及初步临床报道。中国临床神经科学,2001,9(1):5刘正言,周良辅,黄峰平,毛颖。去骨减压对大鼠局灶性脑缺血保护作用的有效时间窗。中国临床神经科学,2001,9(2):162~165刘正言,周良辅,毛颖,黄峰平。去骨减压对大鼠局灶性脑缺血细胞凋亡的影响。中国临床神经科学,2003,11(1):37~41刘正言,周良辅,任惠民,毛颖,黄峰平。去骨瓣减压术对大鼠局灶性脑缺血后脑水肿、血脑屏障、脑血流变化的影响。中国临床神经科学,2006,14(1):72~76董建平刘正言罗志伟董庆汉董辉。经额部小切口—鼻内镜额隐窝开窗联合入路治疗开颅术后额窦脓肿。中国临床神经科学,2006,14(5):512刘正言周良辅毛颖黄峰平丁玎。去骨瓣减压术治疗大面积脑梗死的短期疗效评价。中国临床神经科学,2007,15(1):59~63ZhengyanLiu,YangFan,SeokJoonWon,MelanieNeumann,DezhiHu,LiangfuZhou,PhilipR.Weinstein,JiaingLiu.ChronicTreatmentWithMinocyclinePreservesAdultNewNeuronsandReducesFunctionalImpairmentAfterFocalCerebralIschemia.Stroke,2007,38:146-152(SCI,影响因子5.855)YangFan,ZhengyanLiu*,PhilipR.Weinstein,JohnR.Fike,JialingLiu.Environmentalenrichmentenhancesneurogenesisandimprovesfunctionaloutcomeaftercranialirradiation.EuropeanJournalofNeuroscience,2007,25:38-46(SCI,并列第一作者,影响因子3.949)ShwuhueyMHong,ZhengyanLiu*,YangFan,MelanieNeumann,SeokJoonWon,DianaLac,XuanminLum,PhilipR.Weinstein,JialingLiu.ReducedhippocampalneurogenesisandskillreachingperformanceinadultEmx1mutantmice.ExperimentalNeurology,2007,206(1):24-32.(SCI,并列第一作者,影响因子3.767)JacobRaber,YangFan,YasuhikoMatsumori,ZhengyanLiu,PhilipR.Weinstein,JohnR.Fike,JialingLiu.Irradiationattenuatesneurogenesisandexacerbatesischemia-induceddeficits.AnnNeurol,2004,55(3):381-389(SCI,影响因子7.571)SuhSW,FanY,HongSM,LiuZ,MatsumoriY,WeinsteinPR,SwansonRA,LiuJ.Hypoglycemiainducestransientneurogenesisandsubsequentprogenitorcelllossintherathippocampus.Diabetes,2005,54(2):500-9(SCI,影响因子8.028)Z.Liu,Y.Fan,Y.Matsumori,P.R.Weinstein,J.Liu.Cerebralglobalischemiainducesneurogenesisbutdoesnotincreasethetotalgranulecellpopulationinthedentategyrusofadultgerbils.SocietyforNeuroscience.2003.Z.Liu,Y.Fan,Y.Matsumori,S.Hong,PR.Weinstein,J.Liu.Enrichedenvironmentenhancesprogenitorcellproliferationandsurvivalofnewborncellsinthedentategyrusfollowingtransientcerebralglobalischemia.SocietyforNeuroscience.2004.Z.Liu,Y.Fan,Y.S.Hong,PR.Weinstein,L.Zhou,J.Liu.Minocyclinerestoresneurogenesisandimprovesfunctionalrecoveryafterstrokeinjury:differentefficacyofearlyanddelayedadministration.InternationalSocietyforCerebralBloodFlowandMetabolism.2005.Y.Fan,Z.Liu,Y.Matsumori,P.R.Weinstein,J.R.Fike,J.Liu.LowDoesofIrradiationReducesNeurogenesisbutnottotalgranuleCellPopulationintheDentateGyrusofAdultGerbils.SocietyforNeuroscience.2003Abstract.J.Liu,Y.Fan,ZLiu,T.Kayama,P.R.Weinstein,C.Hsu,Y.Matsumori.Temporaldynamicchangesinneurogenesisandnewborncellsurvivalinthedentategyrusipsilateralandcontralateraltofocalischemiclesion.SocietyforNeuroscience.2003Abstract.Y.Matsumori,Y.Fan,Z.Liu,T.Kayama,A.Sheldon,Z.Vexler,D.M.Ferriero,P.R.Weinstein,J.Liu.HSP70over-expressionprotectstheneonatalbrainsfromhypoxic/ischemicinjury.SocietyforNeuroscience.2003Abstract.Y.Fan,Z.Liu,Y.Matsumori,S.Hong,P.R.Weinstein,J.R.Fike,J.Liu.Environmentalenrichmentrestorestheneurogenesisandenhancesthesurvivalofnewborncellsinthehippocampusofirradiatedadultgerbils.SocietyforNeuroscience.2004Abstract.S.Hong,Y.Matsumori,Y.Fan,Z.Liu,T.Kayama,P.R.Weinstein,C.Hsu,J.Liu.Enrichedenvironmentandphysicalactivityenhancethesurvivalofnewborncellsinthehippocampusaftercerebralfocalischemiainrats.SocietyforNeuroscience.2004Abstract.Y.Matsumori,S.Hong,K.Aoyama,Y.Fan,Z.Liu,T.Kayama,A.R.Sheldon,Z.S.Vexler,D.M.Ferriero,P.R.Weinstein,J.Liu.IncreasedbindingofHSP70toAIFisassociatedwithneuroprotectionagainstneonatalhypoxic/ischemicinjuryinmicewithHSP70over-expression.SocietyforNeuroscience.2004Abstract.